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KMID : 0381019900230060443
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Korean Journal of Nutrition
1990 Volume.23 No. 6 p.443 ~ p.450
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Influence of Alcohol and Low Dietary Copper on Copper Utilization of Maternal and Offspring Liver
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Lee Jong-Ho
Cerklewski, F.L.
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Abstract
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Pregnant rats were fed liquid diet to determine the influence o f maternal ethanol intake on maternal and pup liver copper when dietary copper was low. The diets, which contained either 0.75(low) or 3-75(control)mg copper/1 with or without 30% of kca.1 from ethanol, were fed throughout gestation and the first 15 days of lactation. Maternal calorie intake and body weight were unaffected by dietary treatment. Ethanol intake depressed maternal liver copper concentration only when diet copper was low (interactive effect P〈0.05). Although ethanol intake depressed total pup liver copper concenrration regardless of dietary copper level, the interactive effect observed in maternal liver was reflected in copper content of the pup liver metailothionein fraction elured from a Sephadex G-75 column. The zinc content of mera.llothionein was inversely related to copper contenr of metallorhionein. Results suggest rhar pregnancy and lactation is a special period to develop a copper deficiency when low copper intake and ethanol ingestion are combined not only in mothers but also in their offspring.
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KEYWORD
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copper, alcohol, pregnancy, merallothionein
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